反应详情

This product was prepared from 6-methyl-pyrido[3,4-d]pyrimid-4-one (1.0 eq.) and 3-chloro-4-fluoro-aniline (1.5 eq.) according to the procedure described for Example 61. The crude product from the filtrate was chromatographed on silica using a gradient of 0% to 10% methanol/methylene chloride to afford the free base of the title product which was converted to the title product as described for Example 60 (47%; M.P. 251-258° C.; LC-MS: 289, 291 (MH+); anal. RP-HPLC:4.18 min.).

1. customThe crude product from the filtrate was chromatographed on silica using a gradient of 0% to 10% methanol/methylene chloride