反应详情

To a solution of ethyl 3-(4-{[2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methylidene}-1-piperidinyl)propanoate (D139) (1.5 g, 3.51 mmol) in Ethanol (10 mL) was added Pd/C (0.037 g, 0.351 mmol). The reaction mixture was stirred under hydrogen atmosphere overnight. After filtration, the filtrate was concentrated to afford ethyl 3-(4-{[2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}-1-piperidinyl)propanoate (D140) (1.33 g), which was used directly without further purification. MS (ES): C25H40BNO4 requires 429.3. found 430.2 (M+H+).

1. filtrationAfter filtration
2. concentrationthe filtrate was concentrated