反应详情

温度

80 °C

0.05 g (0.13 mmol) of N-[6-aminopyrid-3-yl]-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide prepared according to the protocol described in step 4.2, 0.056 g (0.26 mmol) of 2-bromo-1-phenylpropan-1-one and 4 mL of acetonitrile are introduced into a 10 mL screw-topped tube equipped with a magnetic bar. The top is then screwed on and the tube is heated at 80° C. with stirring for 24 hours. After this time and cooling to room temperature, the precipitate obtained is filtered off and rinsed successively with 2 mL of acetonitrile and 2 mL of isopropyl ether. The solid obtained is dried under reduced pressure. 0.024 g of the expected product is thus obtained.

1. additionare introduced into a 10 mL screw-topped tube
2. customequipped with a magnetic bar
3. temperatureAfter this time and cooling to room temperature
4. customthe precipitate obtained
5. filtrationis filtered off
6. washrinsed successively with 2 mL of acetonitrile and 2 mL of isopropyl ether
7. customThe solid obtained
8. customis dried under reduced pressure