反应详情

温度

150 °C

0.125 g (0.29 mmol) of N-[2-aminopyrid-4-yl]-5-trifluoromethyl-1-[(3-fluorophenyl)-methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide, prepared according to the protocol described in step 15.2, 0.088 g (0.58 mmol) of 1-bromobutan-2-one and 4 mL of acetonitrile are placed in a 10 mL pressure tube specific for microwave reactors. The tube is then sealed and heated in the microwave reactor at 150° C. for two 1-hour cycles. After this time, the reaction mixture is concentrated under reduced pressure. The crude reaction product is then purified by chromatography on a column of silica gel, eluting with a mixture of dichloromethane and methanol. 0.076 g of the expected product is thus obtained in the form of a yellow solid.

1. customare placed in a 10 mL pressure tube
2. customThe tube is then sealed
3. concentrationAfter this time, the reaction mixture is concentrated under reduced pressure
4. customThe crude reaction product
5. customis then purified by chromatography on a column of silica gel
6. washeluting with a mixture of dichloromethane and methanol