反应详情

A solution of {8-chloro-2-difluoromethoxy-3-[4-(1-isopropyl-1H-pyrazol-3-yl)benzyl]-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester (0.24 g) in tetrahydrofuran (5.0 mL) was treated with 1.0M aqueous sodium hydroxide solution (0.64 mL), and the resulting mixture was stirred at room temperature for 16 hour. The mixture was neutralised by the addition of 1.0M aqueous hydrochloric acid solution (0.64 mL) and then concentrated under reduced pressure. Purification of the residue by preparative reverse-phase HPLC gave the title compound as a white solid (0.051 g).

1. concentrationconcentrated under reduced pressure
2. customPurification of the residue by preparative reverse-phase HPLC