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HRID1947763

反应详情

EQUATION

反应方程式

HRID 1947763 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(Cl)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1
HCID11246676

4-{4-[4-(Trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzene-1-sulfonyl chloride

C16H9ClF3NO2S2

结构：CC(C)(C)OC(=O)N1[C@@H](Cc2ccc(N)cc2)CC[C@@H]1[C@H](O[Si](C)(C)C(C)(C)C)c1ccccc1
HCID57907436

未命名化合物

PRODUCTS

生成物

1
结构：O=S(=O)(Nc1ccc(C[C@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1
HCID53326197

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from tert-butyl (2R,5R)-2-(4-aminobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine-1-carboxylate (i-4-b) and 4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}benzenesulfonyl chloride (i-6) according to the procedure of Example 212, step A. The crude product was purified by preparative TLC plate eluting with 40% ethyl acetate in hexane to afforded the product (8.1 mg, 81%). m/z (ES) 865 (MH)+, 765 (M-Boc)+.

WORKUP

后处理

  1. customThe crude product was purified by preparative TLC plate
  2. washeluting with 40% ethyl acetate in hexane