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HRID1947830

反应详情

EQUATION

反应方程式

HRID 1947830 的结构方程式

REACTANTS

反应物

2
结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(OC)c1)OCC
HCID86654002

未命名化合物

结构：CCOC(=O)[C@H]1CC[C@H](c2ccc(N)c3c2CN(C)C3=O)CC1
HCID178472342

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H]1CC[C@H](c2ccc(Nc3nc(Nc4ccc(CP(=O)(OCC)OCC)cc4OC)ncc3C(F)(F)F)c3c2CN(C)C3=O)CC1
HCID178472346

未命名化合物

PROCEDURE

实验过程

This compound was prepared in a manner analogous to Example 87 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and ethyl trans-4-(7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindol-4-yl)cyclohexanecarboxylate. 1H NMR (400 MHz, MeOD) δ ppm 8.51 (d, J=8.84 Hz, 1H), 8.36 (s, 1H), 7.89 (d, J=8.08 Hz, 1H), 7.40 (d, J=8.84 Hz, 1H), 7.08 (t, J=2.02 Hz, 1H), 6.97 (dt, 1H), 4.53 (s, 2H), 4.06-4.20 (m, 6H), 3.92 (s, 3H), 3.35-3.36 (m, 1H), 3.29-3.31 (m, 1H), 3.20 (s, 3H), 2.44-2.68 (m, 2H), 2.14 (d, J=10.61 Hz, 2H), 1.91-1.98 (m, 2H), 1.57-1.77 (m, 4H), 1.30 (q, 9H). MS (ES+): m/z=734.84 [MH+]. HPLC: tR=1.74 min (UPLC TOF, polar—3 min).

WORKUP

后处理

  1. customHPLC: tR=1.74 min (UPLC TOF, polar—3 min)