反应详情

The title compound was prepared according to the procedure for Example 102 bis(2,2,2-trifluoroethyl)(4-amino-3-methoxybenzyl)phosphonate (Compound 114A, 38 mg, 0.1 mmol) and 2-(2-chloro-5-(trifluoromethyl)pyrimidin-4-ylamino)-N-methylbenzamide (33 mg, 0.1 mmol). The reaction mixture was concentrated in vacuo and the residue was purified by HPLC to afford the title compound. 1H-NMR (DMSO-d6, 400 MHz): δ=2.73 (s, 3H), 3.52 (d, J=21.6 Hz, 2H), 3.73 (s, 3H), 4.60-4.65 (m, 4H), 6.81 (d, J=7.6 Hz, 1H), 6.98 (s, 1H), 7.05 (t, J=7.6 Hz, 1H), 7.34 (t, J=7.2 Hz, 1H), 7.57 (d, J=8.0 Hz, 1H), 7.65 (dd, J=1.2, 7.6 Hz, 1H), 8.34 (s, 1H), 8.38 (s, 1H), 8.68 (d, J=4.4 Hz, 1H), 8.71 (s, 1H), 11.42 (s, 1H). MS (ES+): m/z 676.05 [MH+]; HPLC: tR=3.69 min (ZQ3, polar—5 min).

1. customThe title compound was prepared
2. concentrationThe reaction mixture was concentrated in vacuo
3. customthe residue was purified by HPLC