反应详情

The title compound was prepared according to the procedure for Example 102 using diethyl [(5-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-6-methoxypyridin-2-yl)methyl]phosphonate (Compound 286A, 100 mg, 0.22 mmol) and 7-amino-4-(trans-4-hydroxycyclohexyl)-2-methyl-2,3-dihydro-1H-isoindol-1-one (115 mg, 0.44 mmol). The crude material was purified by MDP to obtain the title compound (82 mg, 55% yield). 1H NMR (400 MHz, methanol-d4) δ=1.31 (t, J=6.9 Hz, 6H), 1.38-1.53 (m, 2H), 1.62-1.77 (m, 2H), 1.84-1.93 (m, 2H), 2.04-2.14 (m, 2H), 2.53-2.64 (m, 1H), 3.17 (s, 3H), 3.44 (d, J=21.7 Hz, 2H), 3.62-3.72 (m, 1H), 4.01 (s, 3H), 4.10-4.21 (m, 4H), 4.51 (s, 2H), 6.99 (dd, J=8.1, 2.8 Hz, 1H), 7.39 (d, J=8.6 Hz, 1H), 8.15 (d, J=7.3 Hz, 1H), 8.37 (s, 2H). MS (ES+): m/z 679.31 (100) [MH+]; HPLC: tR=1.06 min (UPLC, purity).

1. customThe title compound was prepared
2. customThe crude material was purified by MDP