反应详情

According to Scheme 3 Method A: The title compound was prepared from 1-(4-chlorobenzyl)-5-bromopyridin-2(1H)-one (1 eq, 1.80 mmol, 0.55 g, Example 2 Step 1) and 4-methoxy-3-(methylsulfonamido)phenylboronic acid (1.1 eq, 2.00 mmol, 0.49 g) according to the procedure described for Example 1 Step 3. Reaction conditions: 4 hours at 80° C. The crude product was purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2) using CH2Cl2/AcOEt (90/10) then recrystallized from pentane/Et2O to afford N-(5-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methoxyphenyl)methanesulphonamide (0.31 mmol, 0.32 g, 41%) as a white solid.

1. customReaction conditions
2. custom4 hours
3. customat 80° C
4. customThe crude product was purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2)
5. customthen recrystallized from pentane/Et2O