反应详情

According to Scheme 13 Step 1: The title compound was prepared from pyridine-2,4-diol (1 eq, 2.52 mmol, 0.28 g) and 1-(bromomethyl)-3-fluorobenzene (3 eq, 7.56 mmol, 0.93 mL) according to the procedure described for Example 1 Step 2. Reaction conditions: 17 h under reflux in DMF. The crude product was purified by flash chromatography on silica gel (CH2Cl2/AcOEt 90/10) to afford 1-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)pyridin-2(1H)-one as a white solid (0.95 mmol, 0.29 g, 36%).

1. customReaction conditions
2. customThe crude product was purified by flash chromatography on silica gel (CH2Cl2/AcOEt 90/10)