反应详情

3-Phenyl-6-(3-phenyl-propoxy)-indene-1-one (200 mg, 0.586 mmol) obtained in Step 1 was dissolved in carbon tetrachloride, and N-bromosuccinimide (313 mg, 1.75 mmol) and 2,2′-azobisisobutyronitrile (9.7 mg) were added thereto. The mixture was refluxed for 1 hr under the irradiation of a 375 W tungsten lamp. Upon the completion of the reaction, the mixture washed with saturated saline and extracted with dichloromethane. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography (ethyl acetate:hexane=1:5) to obtain 147 mg of the titled compound (yield: 60%) as a red solid.

1. customUpon the completion of the reaction
2. washthe mixture washed with saturated saline
3. extractionextracted with dichloromethane
4. customThe organic layer was separated
5. dry with materialdried over anhydrous MgSO4
6. concentrationconcentrated under a reduced pressure
7. customThe resulting residue was purified by flash chromatography (ethyl acetate:hexane=1:5)