反应详情

A THF (60 mL) solution of 2-carboxymethyl-4-nitrobenzoic acid (3.0 g, 13.3 mmol) was treated with borane-THF complex (53.3 mL, 53.3 mmol) over 15 min at 0° C. The reaction was stirred for 18.5 hrs, quenched with THF/water (1:1, 30 mL), water (20 mL) added and the layers separated. The aqueous layer was backwashed with THF (30 mL), the combined organic phase was washed with brine, dried with magnesium sulfate, and the solvent removed under vacuum to give the product as a white solid (2.05 g, 78%) mp 79-81° C.

1. customquenched with THF/water (1:1, 30 mL), water (20 mL)
2. additionadded
3. customthe layers separated
4. washthe combined organic phase was washed with brine
5. dry with materialdried with magnesium sulfate
6. customthe solvent removed under vacuum