Hydrochloric Acid → 4-(4-Fluorobenzyl)-1-(2-(4-fluorophenoxy)ethyl)piperidine hydrochloride
Reaction equation
Br.[F:2][C:3]1[CH:16]=[CH:15][C:6](C(C2CCNCC2)=O)=[CH:5][CH:4]=1.[C:17]([N:20]1[CH2:25][CH2:24][CH:23]([C:26](=O)[C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH2:22][CH2:21]1)(=O)[CH3:18].[OH-:35].[Na+].[ClH:37]>>[ClH:37].[F:33][C:30]1[CH:31]=[CH:32][C:27]([CH2:26][CH:23]2[CH2:24][CH2:25][N:20]([CH2:17][CH2:18][O:35][C:6]3[CH:15]=[CH:16][C:3]([F:2])=[CH:4][CH:5]=3)[CH2:21][CH2:22]2)=[CH:28][CH:29]=1Participants
Procedure
4-(4-Fluorobenzoyl)piperidine hydrobromide. A solution of 1-acetyl-4-(4-fluoro-benzoyl)piperidine (1.20 g, 4.80 mmol) in HCl (6N, 15 mL) was refluxed for 2 h. The cooled solution was made basic (NaOH) and then extracted with benzene (2×40 mL). The collected organic phase was washed with brine (50 mL), dried and was concentrated under reduced pressure. The free amine was dissolved in HBr (saturated solution in MeOH, 10 mL). The precipitated hydrobromide salt was collected, washed with ether (2×4 mL) and dried in vacuo to afford the title compound as a colorless solid (1.54 g, 98%): mp 198° C.; 1H NMR (CD3OD) 1.80-2.00 (m, 2H), 2.05-2.18 (m, 2H), 3.12-3.28 (m, 2H), 3.40-3.50 (m, 2H), 3.70-3.85 (m, 1H), 4.85 (s, 2H), 7.24 (t, J=8.3 Hz, 2H), 8.10 (dd, J=5.7 and 8.7 Hz, 2H).
Workup
- extractionextracted with benzene (2×40 mL)
- washThe collected organic phase was washed with brine (50 mL)
- customdried
- concentrationwas concentrated under reduced pressure
- dissolutionThe free amine was dissolved in HBr (saturated solution in MeOH, 10 mL)
- customThe precipitated hydrobromide salt was collected
- washwashed with ether (2×4 mL)
- customdried in vacuo
Sources & evidence
- ORD record
- ord-46268b5e9b1043468e2ab5c29130bcef
- Source dataset
- uspto-grants-2000_09
- Patent number
- US06124323
Reaction notes
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