2,4-Dinitrophenol → 4-tert-Butyl-2,6-dinitroanisole

HRID 1956034ノート

反応式

HRID 1956034 の反応式
[N+:1](C1C=C([N+]([O-])=O)C=CC=1O)([O-:3])=[O:2].[N+:14]([C:17]1[CH:22]=[C:21]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:20]=[CH:19][C:18]=1[O:27][CH3:28])([O-:16])=[O:15]>>[N+:14]([C:17]1[CH:22]=[C:21]([C:23]([CH3:25])([CH3:24])[CH3:26])[CH:20]=[C:19]([N+:1]([O-:3])=[O:2])[C:18]=1[O:27][CH3:28])([O-:16])=[O:15]

参加物

3

反応物 2

HCID 14932,4-DinitrophenolHCID 41784474-Tert-butyl-1-methoxy-2-nitrobenzene

生成物 1

HCID 42526024-tert-Butyl-2,6-dinitroanisole収率 99.4%

実験手順

This product was then subjected to hydrolytic separation of the 2,4-dinitrophenol in accordance with the procedure described in Example 6 to afford 6.18 g (98.9% yield) that corresponds to 33.6% of total yield of the 2,4-dinitrophenol separated and 19.37 g 2,6-dinitro-4-tertbutylanisole (95.2% yield, calculated on the theoretical yield possible) contaminated with 3.88 g of the 2-nitro-4-tertbutylanisole. Subsequent crystallization from methyl alcohol (20 ml, cooled -5° C.) afforded 14.72 g of 99.4% pure 2,6-dinitro-4-tertbutylanisole with 57.5% total yield.

後処理

  1. customThis product was then subjected to hydrolytic separation of the 2,4-dinitrophenol in accordance with the procedure
  2. customto afford 6.18 g (98.9% yield) that
  3. customseparated
  4. customtheoretical yield possible)
  5. customSubsequent crystallization from methyl alcohol (20 ml, cooled -5° C.)

出典と根拠

ORDレコード
ord-c5d8de018a8946e297c14bc986d168e7
出典データセット
uspto-grants-1998_07
特許番号
US05777168

反応ノート

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