反应详情

To a 0° C. ether (300 mL) solution of 3-(tertbutyldiphenylsilyloxymethylene)-pentane-1,5-diol (6.9g, 19 mmol) was added methanesulfonyl chloride (4.3 mL, 56 mmol) followed by Et3 N (7.7 mL, 56 mmol). After 3-16 hours, gradually warming to ambient temperature, the reaction was washed with water, brine, dried over MgSO4, and concentrated to give the 1,5-bis(methanesulfonyloxy)-3-(tert-butyldiphenylsilyloxymethylene)-pentane 8.5g (90%) as a colorless oil that was used without further purification.

1. washthe reaction was washed with water, brine
2. dry with materialdried over MgSO4
3. concentrationconcentrated