3-Furoic acid → N-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)furan-3-carboxamide

HRID 1958177Notes

Reaction equation

HRID 1958177 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[O:21]1[CH:25]=[CH:24][C:23]([C:26](O)=[O:27])=[CH:22]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:26]([C:23]3[CH:24]=[CH:25][O:21][CH:22]=3)=[O:27])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 102683-Furoic acidHCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56961281N-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)furan-3-carboxamide

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2, 2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and 3-furancarboxylic acid (CAN 488-93-7) as starting materials; LC-MS (UV peak area/ESI) 98.2%, 395.0414 (M−H)−.

Sources & evidence

ORD record
ord-44b9c3f1ae0349c0920e431381d9cc7f
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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