5-Methoxynicotinic acid → N-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-methoxynicotinamide

HRID 1958191Notes

Reaction equation

HRID 1958191 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH3:21][O:22][C:23]1[CH:24]=[C:25]([C:29](O)=[O:30])[CH:26]=[N:27][CH:28]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:29](=[O:30])[C:25]3[CH:24]=[C:23]([O:22][CH3:21])[CH:28]=[N:27][CH:26]=3)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 47383905-Methoxynicotinic acidHCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 56962001N-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-methoxynicotinamide

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2 ,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and 5-methoxy-3-pyridinecarboxylic acid (CAN 20826-03-3) as starting materials; LC-MS (UV peak area/ESI) 97.8%, 438.0812 (M+H)+.

Sources & evidence

ORD record
ord-752e9e1bc81e4af29ce031523ad19afe
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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