6-(methylcarbamoyl)pyridine-3-carboxylic acid → N5-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-N2-methylpyridine-2,5-dicarboxamide

HRID 1958202Notes

Reaction equation

HRID 1958202 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:20])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH3:21][NH:22][C:23]([C:25]1[N:30]=[CH:29][C:28]([C:31](O)=[O:32])=[CH:27][CH:26]=1)=[O:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:20][C:31]([C:28]3[CH:27]=[CH:26][C:25]([C:23]([NH:22][CH3:21])=[O:24])=[N:30][CH:29]=3)=[O:32])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 151854186-(methylcarbamoyl)pyridine-3-carboxylic acidHCID 672813155-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 67280399N5-(5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-N2-methylpyridine-2,5-dicarboxamide

Procedure

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (example E) and 6-[(methylamino)-carbonyl]-3-pyridinecarboxylic acid (CAN 170464-32-1) as starting materials; MS (EI) 465.2(M+H)+.

Sources & evidence

ORD record
ord-2ce5973d33514846bc49b2b678bf0c81
Source dataset
uspto-grants-2013_04
Patent number
US08410107B2

Reaction notes

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