反应详情

A solution of tert-butyl 5-(2-(hydroxymethyl)-8-phenylimidazo[1,2-a]pyridin-6-yl)thiazol-2-yl(isopropyl)carbamate (75 mg) in 4 ml of TFA was stirred at room temperature for 2 hours. The solvent was evaporated and the residue was made basic with 1 N NaOH and extracted into CH2Cl2. The solvent was removed under vacuum and the residue purified by column chromatography on silica gel using ethyl acetate as eluent to give (6-(2-(isopropylamino)thiazol-5-yl)-8-phenylimidazo[1,2-a]pyridin-2-yl)methanol as a light yellow solid. LCMS (Conditions C): 1.82 min (RT); (M+H)+=365.31 (100%). 1H NMR, 400 MHz, CDCl3/CD3OD: δ 8.08 (d, 1 H), 7.89 (m, 2 H), 7.61-7.31 (m, 6 H), 4.74 (s, 2 H), 3.71 (m, 1 H), 1.32 (d, J=6.4 Hz, 6 H).

1. customThe solvent was evaporated
2. extractionextracted into CH2Cl2
3. customThe solvent was removed under vacuum
4. customthe residue purified by column chromatography on silica gel