反应详情

Tert-butyl 4-(3-methyl-4-oxo-pteridin-6-yl)piperazine-1-carboxylate (25 g, 72.17 mmol) was stirred in NaOH (250 mL of 10% w/w,) and MeOH (250 mL) overnight at RT. The resulting suspension was concentrated and then acidified with formic acid followed by extraction of the aqueous with DCM. The mixture was treated with water, taken to pH 10 and filtered. The aqueous layer was reacidified and the resulting precipitated product was extracted into DCM and concentrated to give the product as a yellow solid (8 g, 24.74 mmol, 34% Yield).

1. customat RT
2. concentrationThe resulting suspension was concentrated
3. extractionfollowed by extraction of the aqueous with DCM
4. additionThe mixture was treated with water
5. filtrationfiltered
6. customthe resulting precipitated product
7. extractionwas extracted into DCM
8. concentrationconcentrated