2,4-Dichloropyridine-3-carbaldehyde → HCID 86645362, compound

HRID 1959599Notes

Reaction equation

HRID 1959599 reaction equation
[Cl:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6]([Cl:10])[CH:5]=[CH:4][N:3]=1.ClC1[C:17]([CH2:18][OH:19])=[C:16](Cl)[CH:15]=[CH:14]N=1.ClC1C=NC=C(Cl)C=1CO.BrC1C=NC=C(Cl)C=1COC1CCCCO1>>[Cl:1][C:2]1[C:7]([CH2:8][O:9][CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][O:19]2)=[C:6]([Cl:10])[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 4

HCID 150539852,4-Dichloropyridine-3-carbaldehydeHCID 17855219(3,5-Dichloropyridin-4-yl)methanolHCID 44190473HCID 44190473, compoundHCID 533931772,4-Dichloropyridine-3-methanol

Product 1

HCID 86645362HCID 86645362, compound

Procedure

2,4-Dichloro-pyridine-3-carbaldehyde (1.565 g. 8.89 mmol) was reduced to (2,4-dichloro-pyridin-3-yl)-methanol according to the procedure described for the preparation of (3,5-dichloro-pyridin-4-yl)-methanol and subsequently protected with the THP-group according to the procedure described for the preparation 3-bromo-5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridine to provide the title compound.

Sources & evidence

ORD record
ord-746704c4ce17408997a6792fbe7a5bfc
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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