反应详情

A solution of N-tert-Butyl-2-methylsulfanyl-2-(3-trimethylsilanylethynyl-quinolin-6-yloxy)-acetamide (215 mg) in methanol (5 ml) was treated with potassium carbonate (18 mg) at room temperature. The reaction mixture was stirred for 1 h. The reaction mixture was diluted with ethyl acetate and washed with 30 ml sat. aq. sodium hydrogen carbonate. The aqueous layer was extracted with 3×50 ml ethyl acetate. The organic layers were combined, dried over sodium sulfate, filtered and evaporated. The residue was purified by column chromatography (heptane/ethyl acetate 6:4) to give N-tert-Butyl-2-(3-ethynyl-quinolin-6-yloxy)-2-methylsulfanyl-acetamide (125 mg) as brownish solid.

1. washwashed with 30 ml sat. aq. sodium hydrogen carbonate
2. extractionThe aqueous layer was extracted with 3×50 ml ethyl acetate
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe residue was purified by column chromatography (heptane/ethyl acetate 6:4)