4-Aminophenyl trifluoromethyl sulphone → 6-Benzyl-5,6,7,8-tetrahydro-N-(4-(trifluoromethylsulfonyl)phenyl)pyrido[4,3-d]pyrimidin-4-amine

HRID 19632Notes

Reaction equation

HRID 19632 reaction equation
[CH2:1]([N:8]1[CH2:18][CH2:17][C:11]2[N:12]=[CH:13][N:14]=[C:15](Cl)[C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]([F:32])([F:31])[S:21]([C:24]1[CH:30]=[CH:29][C:27]([NH2:28])=[CH:26][CH:25]=1)(=[O:23])=[O:22]>>[CH2:1]([N:8]1[CH2:18][CH2:17][C:11]2[N:12]=[CH:13][N:14]=[C:15]([NH:28][C:27]3[CH:29]=[CH:30][C:24]([S:21]([C:20]([F:32])([F:19])[F:31])(=[O:23])=[O:22])=[CH:25][CH:26]=3)[C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1363154-Aminophenyl trifluoromethyl sulphoneHCID 253240466-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido(4,3-d)pyrimidine

Product 1

HCID 593465576-Benzyl-5,6,7,8-tetrahydro-N-(4-(trifluoromethylsulfonyl)phenyl)pyrido[4,3-d]pyrimidin-4-amine

Procedure

The title compound was prepared substantially according to the procedure given for Compound 4A, using 6-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (0.2 g, 0.77 mmol), and 4-(trifluoromethylsulphonyl)aniline (0.27 g, 1.2 mmol) to give the desired N-benzyl intermediate as a brown solid (278 mg. 82%).

Sources & evidence

ORD record
ord-fdbd2b5726a34856978ab33f6196a493
Source dataset
uspto-grants-2010_06
Patent number
US07745451B2

Reaction notes

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