反应详情

1-(Methoxycarbonyl)-2-(4-(trifluoromethyl)benzyl)piperidine-4-carboxylic acid (14.65 g, 42.43 mmol) was suspended in MTBE (150 mL) and heated under reflux for 1 min, then stirred at room temperature for 3 days. The solids were isolated and dried under vacuum. Cis-1-(methoxycarbonyl)-2-(4-(trifluoromethyl)benzyl)piperidine-4-carboxylic acid (9.3 g, 63.5%) was isolated. 1H NMR (600 MHz, cd3od) δ 1.68-1.77 (m, 1H), 1.90-1.97 (m, 1H), 1.99-2.10 (m, 2H), 2.58-2.64 (m, 1H), 2.83-2.89 (m, 1H), 2.93-3.00 (m, 1H), 3.16-3.31 (m, 1H), 3.43 (s, 3H), 3.86-3.92 (m, 1H), 4.31-4.36 (m, 1H), 7.36 (d, 2H), 7.53 (d, 2H).

1. temperatureheated
2. temperatureunder reflux for 1 min
3. customThe solids were isolated
4. customdried under vacuum