HRID1963504

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22502148

未命名化合物

反应SMILES：Cn1nnnc1C1CC(c2cc(=O)[nH]o2)CCN1C(=O)OCc1ccccc1

HCID66734753

未命名化合物

PRODUCTS

产物

反应SMILES：Cn1nnnc1[C@H]1C[C@@H](c2cc(=O)[nH]o2)CCN1C(=O)OCc1ccccc1

HCID66739232

未命名化合物

收率 47.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Benzyl 2-(1-methyl-1H-tetrazol-5-yl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (488 mg, 1.27 mmol) was subjected to chiral preparative HPLC (Column: Chiralpak AS (250×20), 5 μm particle size, mobile phase: Heptane/EtOH/DEA 60/40/0.1, flow rate 18 mL/min) to yield (2R,4S)-benzyl 2-(1-methyl-1H-tetrazol-5-yl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (231 mg, 47%), chiral purity 98% ee, Optical rotation [α]D20=+14.5 (acetonitrile, c=1)