反应详情

A suspension of 2-isopropyl-5-nitro-1H-indole (100 mg, 0.49 mmol) and Raney Nickel (10 mg) in MeOH (10 mL) was hydrogenated under hydrogen (1 atm) at the room temperature overnight. The catalyst was filtered off through a celite pad and the filtrate was evaporated under vacuum to give a residue, which was purified by column (petroleum ether/ethyl acetate=5/1) to give 2-isopropyl-1H-indol-5-amine (35 mg, 41%). 1H NMR (400 MHz, CDCl3) δ 7.69 (br s, 1 H), 7.10 (d, J=8.4 Hz, 1 H), 6.86 (d, J=2.4 Hz, 1 H), 6.58 (dd, J=2.4, 8.8 Hz, 1 H), 6.07 (t, J=1.2 Hz, 1 H), 3.55 (br s, 2 H), 3.06-2.99 (m, 1 H), 1.33 (d, J=7.2 Hz, 6 H); MS (ESI) m/e (M+H+) 175.4.

1. customwas hydrogenated under hydrogen (1 atm) at the room temperature overnight
2. filtrationThe catalyst was filtered off through a celite pad
3. customthe filtrate was evaporated under vacuum
4. customto give a residue, which
5. customwas purified by column (petroleum ether/ethyl acetate=5/1)