反应详情

温度

25 °C

To a stirred solution of (R)-tert-butyl 2-(6-fluoro-3-oxo-1-tosylpyrrolo[4,3,2-de][2,6]naphthyridin-4(1H,3H,5H)-yl)-3-methylbutanoate (933 mg, 1.860 mmol) in MeOH (4 mL) was added aqueous NaOH (1N, 2 mL). The reaction mixture was stirred at 25° C. for 40 min. The reaction was partitioned between DCM and brine. The organics were dried over MgSO4 and concentrated. Purification by silica column chromatography (MeOH/DCM, 0-5%) afforded the title compound as a yellow oil (0.39 g, 60.4%). [M+H] calc'd for C18H22FN3O3, 348; found, 348.5.

1. customThe reaction was partitioned between DCM and brine
2. dry with materialThe organics were dried over MgSO4
3. concentrationconcentrated
4. customPurification by silica column chromatography (MeOH/DCM, 0-5%)