反应详情

A mixture of [1-({(4-Bromo-phenyl)-[trans-2-(6-fluoro-pyridin-2-yl)-cyclopropanecarbonyl]-amino}-methyl)-cyclopentyl]-carbamic acid t-butyl ester (95 mg, 0.18 mmol), arylboronic acid (0.22 mmol), Pd(PPh3)2Cl2 (14 mg, 0.02 mmol) and K2CO3 (47 mg, 0.34 mmol) in CH3CN/H2O (3.5/0.5 mL) was macrowaved at 140° C. for 20 min. The reaction mixture was passed through a short silica pad (EtOAc) and concentrated. The residue was subjected to ISCO (12 g column, 0-50% EtOAc in hexaneover 25 min) to give the desired products. MS (MH+ 572).

1. concentrationconcentrated
2. customwas subjected to ISCO (12 g column, 0-50% EtOAc in hexaneover 25 min)