(1R,3R,4S)-3-ethyl-4-(6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanol → 3-ethyl-4-(6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanone

HRID 1969885Notes

Reaction equation

HRID 1969885 reaction equation
[CH2:1]([C@H:3]1[C@@H:7]([C:8]2[N:12]3[C:13]4[CH:19]=[CH:18][N:17]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[C:14]=4[N:15]=[CH:16][C:11]3=[N:10][N:9]=2)[CH2:6][C@@H:5]([OH:28])[CH2:4]1)[CH3:2].C([C@H]1[C@@H](C2N3C4C=CN(COCC[Si](C)(C)C)C=4N=CC3=NN=2)C[C@H](O)C1)C>>[CH2:1]([CH:3]1[CH:7]([C:8]2[N:12]3[C:13]4[CH:19]=[CH:18][N:17]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:25])([CH3:27])[CH3:26])[C:14]=4[N:15]=[CH:16][C:11]3=[N:10][N:9]=2)[CH2:6][C:5](=[O:28])[CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 67997870(1R,3R,4S)-3-ethyl-4-(6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanolHCID 67997980(1S,3R,4S)-3-ethyl-4-(6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanol

Product 1

HCID 585572963-ethyl-4-(6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanone

Procedure

A solution of 3-ethyl-4-((6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanone (0.296 g, 0.741 mmol) in THF (2.96 mL) was cooled to about 0° C. and to it was added DIBAL-H (1M in cyclohexane, 1.482 mL, 1.482 mmol). The reaction was stirred for about 45 min. The reaction was quenched with MeOH (3 mL). To the reaction mixture was added saturated aqueous NH4Cl (10 mL) and EtOAc (10 mL). The organic layer was collected and washed with brine (10 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to provide the crude material. The crude material was purified by silica gel column chromatography using 0-5% MeOH/CH2Cl2 to provide a scalemic mixture enriched in (1S,3R,4S)-3-ethyl-4-(6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanol (148 mg, 0.369 mmol, 50%) and a scalemic mixture enriched in (1R,3R,4S)-3-ethyl-4-(6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanol (60 mg, 0.149 mmol, 20%) both as amorphous solids. LC/MS (Table 1, Method a) Rt=2.37 min; MS m/z: 402 (M+H)+ and Rt=2.16 min; MS m/z: 402 (M+H)+ respectively.

Workup

  1. customThe crude material was purified by silica gel column chromatography
  2. customto provide a scalemic mixture

Sources & evidence

ORD record
ord-3bf404cf44de45509751b23a6747c11e
Source dataset
uspto-grants-2013_04
Patent number
US08426411B2

Reaction notes

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