反应详情

Prepared in accordance with Method B with methyl isocyanoacetate (2.46 g, 24.63 mmol) and piperidine (3.22 mL, 37.85 mmol). The reaction mixture was stirred 1 h at RT and then concentrated. The residue was dissolved in dichloromethane (50 mL) and the organic layer was washed with 10% aqueous citric acid (2×25 mL), dried over MgSO4, filtered and evaporated. 2-Isocyano-1-(piperidin-1-yl)ethanone SLA 07116B was obtained as an orange solid (3.13 g, 83% yield).

1. concentrationconcentrated
2. dissolutionThe residue was dissolved in dichloromethane (50 mL)
3. washthe organic layer was washed with 10% aqueous citric acid (2×25 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated