反应详情

To a solution of 1-(4-methylphenyl)-2-cyanopyrrole (1.274 g) in tetrahydrofuran (25 ml) is added N-bromosuccinimide (1.776 g) in several portions at room temperature. After being stirred for 3 hours at ambient temperature, the mixture is concentrated in vacuo. The residue is treated with diethyl ether. The precipitates are removed by filtration and washed with a small amount of diethyl ether. The filtrates are concentrated in vacuo to give an oily residue, which is purified by silicagel column chromatography (elution by 40% methylene chloride in n-hexane) to yield 1-(4-methylphenyl)-4-bromo-2-cyanopyrrole as a solid.

1. concentrationthe mixture is concentrated in vacuo
2. additionThe residue is treated with diethyl ether
3. customThe precipitates are removed by filtration
4. washwashed with a small amount of diethyl ether
5. concentrationThe filtrates are concentrated in vacuo
6. customto give an oily residue, which
7. customis purified by silicagel column chromatography (elution by 40% methylene chloride in n-hexane)