反应详情

2.16 g (3.26 mmole) of (S)—N-[2-[2-(R)-(1,1-dimethylethyloxycarbonylamino)-3-phenylpropionyloxy]-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidoyl chloride (Z)-2-butenedioate (1:1) (see Example 18) was suspended in 40 ml of methanol and boiled for 1 hour, then evaporated to dryness. The residue was triturated with 20 ml of ethyl acetate, the precipitate was filtered, washed with ethyl acetate. This crude product was recrystallized in isopropyl alcohol to yield the title compound.

1. customevaporated to dryness
2. customThe residue was triturated with 20 ml of ethyl acetate
3. filtrationthe precipitate was filtered
4. washwashed with ethyl acetate
5. customThis crude product was recrystallized in isopropyl alcohol