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HRID1976809

反应详情

EQUATION

反应方程式

HRID 1976809 的结构方程式

REACTANTS

反应物

2
结构：O.[Li+].[OH-]
HCID168937

Lithium hydroxide, monohydrate

H3LiO2

结构：COC(=O)CCCOc1cc([N+](=O)[O-])c(C(C)O)cc1OC
HCID10591264

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(C(C)O)c([N+](=O)[O-])cc1OCCCC(=O)O
HCID3437287

4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyric acid

C13H17NO7

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Methyl 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyrate (5.04 g) from above was stirred with lithium hydroxide monohydrate in methanol using conventional protocols. 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyric acid was obtained as an amorphous yellow solid (4.0 g, 83%). 1H NMR (CDCl3) δ 1.34 (3H, d, J=11 Hz, MeCOH), 2.03 (2H, m, CCH2C), 2.38 (2H, t, J=7.3 Hz, CH2CO), 3.81 (3H, s, OMe), 3.96 (2H, t, J=7.4 Hz, CH2O), 4.13 (2H, brs, OH), 5.38 (1H, q, J=10.8 Hz, CHOH), 7.19 (1H, s, aromatic, and 7.43 (1H, s, aromatic).