反应详情

A solution of 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propoxyamine (74 mg, 0.20 mmol, prepared in the preceding step) and 1H-pyrazole-1-carboxamidine hydrochloride (60 mg, 0.41 mmol) in anhydrous N,N-dimethylformamide (2 mL) was stirred at ambient temperature overnight. Additional 1H-pyrazole-1-carboxamidine hydrochloride (30 mg, 0.20 mmol) was added, and the reaction was stirred at ambient temperature for 3 days. N,N-Dimethylformamide was removed in vacuo, then the residue was treated with acetonitrile. The mixture was filtered to remove excess 1H-pyrazole-1-carboxamidine hydrochloride, and the filtrate was concentrated in vacuo. The residual oil was partitioned between diethyl ether (10 mL) and water (10 mL). The aqueous layer was washed with diethyl ether (2×10 mL), adjusted to pH 8 with 2N NaOH, and extracted with ethyl acetate (2×10 mL). The ethyl acetate extracts were washed with pH 7 buffer (2×15 mL) and brine (15 mL), dried over Na2SO4, filtered, and evaporated to give the title compound (64 mg, 78%) as a colorless oil. 1H-NMR (300 MHz, DMSO-d6) δ7.76 (ddd, 1H, J=8.4, 7.4, 1.8 Hz), 7.69 (dd, 1H, J=7.9, 1.6 Hz), 7.37 (d, 1H, J=7.7 Hz), 7.09 (dt, 1H, J=7.9, 1.0 Hz), 6.69 (s, 1H), 6.47 (s, 1H), 6.33 (t, 1H, J=2.1 Hz), 4.00 (s, 3H), 3.92 (t, 2H, J=6.5 Hz), 3.70 (t, 2H, J=6.1 Hz), 2.20 (s, 3H), 1.88 (pentet, 2H, J=6.3 Hz). Mass spectrum (MALDI-TOF, α-cyano-4-hydroxycinnamic acid matrix) calcd. for C18H23N3O6S: 410.1 (M+H), 432.1 (M+Na). Found: 410.1, 432.6.

1. stirringthe reaction was stirred at ambient temperature for 3 days
2. customN,N-Dimethylformamide was removed in vacuo
3. additionthe residue was treated with acetonitrile
4. filtrationThe mixture was filtered
5. customto remove excess 1H-pyrazole-1-carboxamidine hydrochloride
6. concentrationthe filtrate was concentrated in vacuo
7. customThe residual oil was partitioned between diethyl ether (10 mL) and water (10 mL)
8. washThe aqueous layer was washed with diethyl ether (2×10 mL)
9. extractionextracted with ethyl acetate (2×10 mL)
10. washThe ethyl acetate extracts were washed with pH 7 buffer (2×15 mL) and brine (15 mL)
11. dry with materialdried over Na2SO4
12. filtrationfiltered
13. customevaporated