Hydrochloric Acid → HCID 178478700, compound

HRID 1978359Notes

Reaction equation

HRID 1978359 reaction equation
C(OC([NH:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([CH2:16][N:17]2[CH2:22][CH2:21][CH:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:19][CH2:18]2)[CH2:12][CH2:11]1)=O)(C)(C)C.[ClH:29]>C(O)C>[ClH:29].[ClH:29].[NH2:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([CH2:16][N:17]2[CH2:18][CH2:19][CH:20]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:21][CH2:22]2)[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453595HCID 178453595, compound

Product 1

HCID 178478700HCID 178478700, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.02 g (2.64 mM) of l-[trans-4-[N-(tert-butoxycarbonyl)aminomethyl]-1-cyclohexylmethyl]-4-phenylpiperidine in ethanol (10 ml) was added 10 ml (120 mM) of 12N-hydrochloric acid at room temperature and the mixture was stirred for one hour. This reaction mixture was concentrated under reduced pressure (crystals separated out) and diethyl ether was added to the residue. The resulting crystal crop was harvested by filtration and rinsed with ethanol and diethyl ether to provide the title compound as light-purple crystals.

Workup

  1. concentrationThis reaction mixture was concentrated under reduced pressure (crystals separated out) and diethyl ether
  2. additionwas added to the residue
  3. filtrationThe resulting crystal crop was harvested by filtration
  4. washrinsed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-cd060ba8e47148ccab58becf46f9a8bf
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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