Hydrochloric Acid → HCID 21994179, compound

HRID 1978364Notes

Reaction equation

HRID 1978364 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:29]=[CH:28][C:13]([CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:17][CH2:16]2)=[CH:12][CH:11]=1)=O)(C)(C)C.[ClH:30]>C(O)C>[ClH:30].[ClH:30].[NH2:8][CH2:9][C:10]1[CH:29]=[CH:28][C:13]([CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:17][CH2:16]2)=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993837HCID 21993837, compound

Product 1

HCID 21994179HCID 21994179, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 5.77 g (14.6 mM) of 1-[4-[N-(tert-butoxycarbonyl)aminomethyl]benzyl]-4-benzylpiperidine was added 10 ml (120 mM) of 12N-hydrochloric acid at room temperature and the mixture was stirred at the prevailing temperature for one hour. After addition of ethanol, the mixture was concentrated under reduced pressure and ethanol and diethyl ether were added to the residue. The resulting crystal crop was harvested by filtration and rinsed with ethanol and diethyl ether to provide the title compound as white crystals.

Workup

  1. concentrationthe mixture was concentrated under reduced pressure and ethanol and diethyl ether
  2. additionwere added to the residue
  3. filtrationThe resulting crystal crop was harvested by filtration
  4. washrinsed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-011ed120643e48e48f0dc515da08a389
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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