Triethylsilane → 7-Bromo-2,3,4,5-tetrahydro-1-benzoxepine

To a solution of 7-bromo-3,4-dihydro-1-benzoxepin-5(2H)-one (20.0 g) in trifluoroacetic acid (32 ml) was added at room temperature triethylsilane (29.2 ml), and the mixture was stirred for 2 hours and concentrated under reduced pressure. To the residue was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate solution and saturated brine, dried with magnesium sulfate and concentrated under reduced pressure. The residue was distilled under reduced pressure (0.8 mmHg/123° C.) to give colorless oil. The obtained oil (13.12 g) was dissolved in ethanol (200 ml), and to the solution was added platinum oxide (0.4 g). The mixture was stirred under hydrogen atmosphere for 24 hours. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified with silica gel column chromatography (hexane→ethyl acetate/hexane=1:19) to give colorless oil of 7-bromo-2,3,4,5-tetrahydro-1-benzoxepine (9.61 g).

1. concentrationconcentrated under reduced pressure
2. additionTo the residue was added water
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with saturated sodium bicarbonate solution and saturated brine
5. dry with materialdried with magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. distillationThe residue was distilled under reduced pressure (0.8 mmHg/123° C.)
8. customto give colorless oil
9. stirringThe mixture was stirred under hydrogen atmosphere for 24 hours
10. customThe catalyst was removed by filtration
11. concentrationthe filtrate was concentrated under reduced pressure
12. customThe residue was purified with silica gel column chromatography (hexane→ethyl acetate/hexane=1:19)

ORD record

ord-dfaf45ae5e004778a5dd669bacef5119

Source dataset

uspto-grants-2001_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06235771B1