反应详情

To methyl 7-(4-ethoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate (960 mg) were added THF (19.2 ml), methanol (9.6 ml) and 1N sodium hydroxide (3.4 ml), and the mixture was stirred at room temperature for 3 hours. Under reduced pressure, the organic solvent was evaporated. To the residue was added ethyl acetate, and the mixture was extracted with water. To the mixture was added 6N hydrochloric acid (2 ml), and the mixture was extracted with ethyl acetate/THF, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated to give 7-(4-ethoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid (850 mg).

1. customUnder reduced pressure, the organic solvent was evaporated
2. additionTo the residue was added ethyl acetate
3. extractionthe mixture was extracted with water
4. additionTo the mixture was added 6N hydrochloric acid (2 ml)
5. extractionthe mixture was extracted with ethyl acetate/THF
6. washwashed with saturated brine
7. dry with materialdried with magnesium sulfate
8. customUnder reduced pressure, the solvent was evaporated