反应详情

143 g of 6-carboxymethyl-4-hydroxy-1,3,3a,7-tetraazaindene prepared in Synthesis Example 1 and 98 g of vinylbenzylamine were dissolved in 1 l of dimethylformamide with stirring at room temperature. To the solution, 152 g of N,N-dicyclohexylcarbodiimide was added dropwise. After addition, the mixture was stirred at room temperature for 6 hours to separate white crystals (N,N-dicyclohexylurea). After the reaction, the separated crystals were filtered off and the filtrate was poured into 2 l of water to separate white crystals. The separated crystals were filtered out and recrystallized from acetonitrile to obtain 180 g of the desired 4-hydroxy-6-(N-vinylbenzylcarbamoylmethyl)-1,3,3a,7-tetraazaindene.

1. additionAfter addition
2. stirringthe mixture was stirred at room temperature for 6 hours
3. customto separate white crystals (N,N-dicyclohexylurea)
4. customAfter the reaction
5. filtrationthe separated crystals were filtered off
6. additionthe filtrate was poured into 2 l of water
7. customto separate white crystals
8. filtrationThe separated crystals were filtered out
9. customrecrystallized from acetonitrile