反应详情

A solution of 9.9 g (0.042 mol) of 4-bromobiphenyl in 50 ml of dry tetrahydrofuran was cooled to -78° under nitrogen and stirred while 26.5 ml (0.042 mol) of 1.6 molar n-butyllithium in hexane was added dropwise over 15 minutes. A thick slurry formed, and 35 ml of tetrahydrofuran was added to facilitate stirring. With continued cooling, 5.9 ml (6.7 g, 0.046 mol) of chlorochloromethyldimethylsilane was added over 10 minutes, giving a clear solution that was allowed to warm to room temperature. Addition of 300 ml of ether, filtration to remove precipitated lithium chloride, and evaporation of the filtrate left 13.2 g of semisolid. Redissolution in ether, filtration, and evaporation of the filtrate left 11.0 g (100% crude) of the title compound as a colorless solid, m.p. 30°-40°, suitable for further reaction. Trace impurities could be removed by sublimation at 30°/0.1 mm, leaving the title compound unsublimed in 83% recovery; m.p. 37°-40°; ir (Nujol®) 1585, 1240, 1110, 830, 810, 750, 690 cm-1, nmr (CDCl3) 0.4 (6H, s), 2.9 (2H, s), 7.3-7.7 (9H, m).

1. additionwas added dropwise over 15 minutes
2. customA thick slurry formed
3. temperatureWith continued cooling
4. customgiving a clear solution that
5. customto remove
6. customprecipitated
7. customlithium chloride, and evaporation of the filtrate
8. waitleft 13.2 g of semisolid
9. filtrationRedissolution in ether, filtration, and evaporation of the filtrate
10. waitleft 11.0 g (100% crude) of the title compound as a colorless solid, m.p. 30°-40°
11. customsuitable for further reaction
12. customTrace impurities could be removed by sublimation at 30°/0.1 mm