反应详情

In 50 ml of chloroform was dissolved 4.6 g of 1-(4-chloro-6-quinazolinesulfonyl)-4-(2-ethoxy-2-phenylethyl)piperazine, and to the solution were added 1.7 g of N-methyl-N-cyclohexylamine and 1 g of anhydrous potassium carbonate, and the mixture was stirred at a temperature of 20° C. to 25° C. for 3 hours. The reaction solution thus obtained was washed with water, dried with anhydrous potassium carbonate and then chloroform was distilled therefrom. The residue was subjected to the same silica gel-column chromatography as in Example 1 using chloroform as the solvent for purification to give 4.2 g of 1-[4-(N-methyl-N-cyclohexylamino)-6-quinazolinesulfonyl]-4-(2-ethoxy-2-phenylethyl)piperazine [i.e., Compound (19)] in a yield of 79%.

1. customThe reaction solution thus obtained
2. washwas washed with water
3. dry with materialdried with anhydrous potassium carbonate
4. distillationchloroform was distilled
5. customThe residue was subjected to the same silica gel-column chromatography as in Example 1 using chloroform as the solvent for purification