反应详情

4.80 g. of ethyl 4-{[2-[(2,6-dichlorophenyl)imino]-1-imidazolidinyl]oxy}butyrate are dissolved in 100 ml. of ethanol, 26.6 ml. of 1N caustic soda solution are added at room temperature and the mixture is left to stand overnight. The solution is then neutralized with 26.6 ml. of 1N hydrochloric acid and evaporated in vacuo. The dried residue is digested with a hot 1:1 mixture of acetonitrile/ethyl acetate/chloroform. The salt is then filtered off from the solution and the filtrate is evaporated in vacuo. The residue is recrystallized from hot acetonitrile, whereupon 4-{[2-[(2,6-dichlorophenyl)imino]-1-imidazolidinyl]oxy}-butyric acid, m.p. 115°-116° (from acetonitrile) is obtained.

1. waitthe mixture is left
2. customof 1N hydrochloric acid and evaporated in vacuo
3. additionThe dried residue is digested with a hot 1:1 mixture of acetonitrile/ethyl acetate/chloroform
4. filtrationThe salt is then filtered off from the solution
5. customthe filtrate is evaporated in vacuo
6. customThe residue is recrystallized from hot acetonitrile, whereupon 4-{[2-[(2,6-dichlorophenyl)imino]-1-imidazolidinyl]oxy}-butyric acid
7. customm.p. 115°-116° (from acetonitrile) is obtained