反应详情

40.75 g (0.1 mole) of 3-(4-trifluoromethylphenyl)-7-chloro-10-hydroxy-3,4-dihydroacridine-1,9(2H,10H)-dione are suspended in 500 ml of ethanol, 11.5 g (0.1 mole) of N-methyl-N'-aminopiperazine are added and the reaction mixture is heated to reflux for 30 minutes. A clear orange-red solution forms during this. After cooling down, the ethanol is distilled out in a rotary evaporator and the solid residue is recrystallized from toluene/cyclohexane (1:1). 43 g=85% of theory of the title compound is thus obtained in the form of orange-yellow crystals of melting point 213° C.

1. temperaturethe reaction mixture is heated
2. temperatureto reflux for 30 minutes
3. temperatureAfter cooling down
4. distillationthe ethanol is distilled out in a rotary evaporator
5. customthe solid residue is recrystallized from toluene/cyclohexane (1:1)