反应详情

2,4-Dichloro-5-methyl-N-{6-methyl-5-[4-(piperidine-1-sulfonyl)-phenylsulfanyl]-pyridin-2-yl}-benzenesulfonamide was prepared from 2-amino-5-bromo-6-methylpyridine and 4-(N-piperidinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichloro-5-methylphenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 9.58 (1H, br s, NH), 8.09 (1H, s, A-ring CH ortho to 2×Cl), 7.67 & 6.97 (2×1H, 2×d, 2×J 11 Hz, pyridyl CH's),7.62 & 7.12 (2×2H, 2×d, 2×J 10 Hz, Ar CH's of C-ring), 7.51 (1H, s, A-ring CH ortho to SO2NH), 3.01-2.93 (4H, m, CH2NCH2), 2.50 & 2.41 (2×3H, 2×s, 2×CH3), 1.70-1.60 (4H, m, CH2CH2CH2CH2CH2), 1.47-1.38 (2H, m, CH2CH2CH2CH2CH2). Hplc (Luna 2, Gradient 5): rt=6.72 minutes. LC/MS rt=7.34 minutes, 586/588 (MH+).

1. customrt=6.72 minutes
2. customLC/MS rt=7.34 minutes, 586/588 (MH+)