反应详情

A solution of 3-(4-{2-[3-Ethyl-2-oxo-1-(4-trifluoromethyl-benzyl)-imidazolidin-4-yl]-ethoxy}-phenyl)-2-methyl-2-phenoxy-propionic acid ethyl ester (0.31 g, 0.518 mmol) and 5N NaOH (1 mL) in ethanol (9 mL) is refluxed for 1 hour, cooled to ambient temperature, and concentrated. The residue is diluted with CH2Cl2, washed, dried, and concentrated in vacuo to provide the title compound (0.256 g, 87%). 1H NMR (400 MHz, CDCl3): δ 7.54 (d, 2H, J=7.6 Hz), 7.35 (d, 2H, J=8.4 Hz), 7.21-7.17 (m, 4H), 6.97 (t, 1H, J=7.6 Hz), 6.88 (d, 2H, J=7.6 Hz), 6.72 (d, 2H, J=8.4 Hz), 4.42, 4.38 (ABq, 2H, J=15.1 Hz), 3.94 (t, 2H, J=5.9 Hz), 3.87-3.81 (m, 1H), 3.62-3.53 (m, 1H), 3.36 (t, 1H, J=8.4 Hz), 3.31, 3.08 (ABq, 2H, J=8.4 Hz), 3.15-3.08 (m, 1H), 3.00 (t, 1H, J=8.4 Hz), 2.23-2.19 (m, 1H), 1.89-1.82 (m, 1H), 1.37 (s, 3H), 1.13 (t, 3H, J=6.7 Hz). MS [EI+] 571 (M+H)+, [EI−] 569 (M−H)+.

1. concentrationconcentrated
2. additionThe residue is diluted with CH2Cl2
3. washwashed
4. customdried
5. concentrationconcentrated in vacuo