反应详情

Following the procedure as described in Example 1, making variations only as required to use 4-fluorobenzylamine in place of isoamylamine to react with 6-[4-(5-fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl]imidazo[1,2-b]pyridazine-2-carboxylic acid ethyl ester, the title compound was obtained as a white solid in 38% yield. 1H NMR (300 MHz, CDCl3) δ 8.19 (d, J=3.0 Hz, 1H), 7.76-7.72 (m, 1H), 7.69-7.6 (m, 2H), 7.35-7.3 (m, 2H), 7.27-7.19 (m, 1H), 7.09-6.94 (m, 3H), 6.89 (d, J=9.9 Hz, 1H), 4.59 (d, J=6.3 Hz, 2H), 4.05-3.94 (m, 1H), 3.91-3.8 (m, 1H), 3.69-3.54 (m, 2H), 3.52-3.43 (m, 2H), 3.38-3.29 (m, 2H). 13C NMR (75 MHz, CDCl3) δ 166.0, 162.6, 162.1, 160.5, 154.8, 137.6, 135.5, 134.1, 134.0, 129.7, 129.6, 126.2, 118.6, 116.8, 116.6, 115.6, 115.3, 114.9, 114.6, 112.2, 46.2, 45.6, 42.5, 41.3. MS (ES+) m/z 508 (M+1).