4-Aminothiophenol → HCID 178434132, compound

HRID 1987647Notes

Reaction equation

HRID 1987647 reaction equation
[CH2:1]([C:8]1=[N:9][NH:10][C:11](=[O:24])/[C:12]/1=[C:13]1\[NH:14][C:15]2[C:20]([C:21](Cl)=[CH:22]\1)=[CH:19][CH:18]=[CH:17][CH:16]=2)C1C=CC=CC=1.[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([SH:32])=[CH:28][CH:27]=1>>[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([S:32][C:21]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14]/[C:13](=[C:12]3/[C:8]([CH3:1])=[N:9][NH:10][C:11]/3=[O:24])/[CH:22]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 145104-AminothiophenolHCID 178518914HCID 178518914, compound

Product 1

HCID 178434132HCID 178434132, compound

Procedure

The title compound was prepared from (Z)-3-benzyl-4-(4-chloroquinolin-2(1H)-ylidene)-1H-pyrazol-5(4H)-one and 4-aminothiophenol under conditions similar to those described in Example 6. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.81 (s, 2H) 6.77-6.79 (m, 3H) 7.23-7.30 (m, 3H) 7.33 (d, J=8.34 Hz, 2H) 7.40-7.48 (m, 2H) 7.64 (t, J=7.45 Hz, 1H) 7.88 (t, J=7.83 Hz, 1H) 7.96 (d, J=8.59 Hz, 1H) 8.14 (d, J=8.08 Hz, 1H); ESI-MS: m/z calc'd for C25H20N4OS 424.14. found 424.2 (M+H)+.

Sources & evidence

ORD record
ord-4ddec3658f754d9ca24db3df3bea0a2e
Source dataset
uspto-grants-2009_06
Patent number
US07550598B2

Reaction notes

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