反应详情

A solution of the product from Example 2A (100 mg, 0.34 mmol), 4-cyanophenyl boronic acid (65 mg, 0.44 mmol), dichlorobis(triphenylphosphine)palladium(II) (12 mg, 17 μmol) and potassium carbonate (120 mg, 0.85 mmol) under an atmosphere of nitrogen in isopropyl alcohol (8 mL) was heated at reflux for 5 hrs. Then, the reaction mixture was cooled to ambient temperature. The mixture was partitioned between ethyl acetate (25 mL) and H2O (10 mL). The organic layer was washed with brine, dried with magnesium sulfate, filtered, concentrated, and chromatographed on silica gel, eluting with 3% (9:1 MeOH:conc NH4OH) in dichloromethane to provide 36 mg of the title compound. 1H NMR (300 MHz, CD3OD) δ 1.21 (d, J=6 Hz, 3 H), 1.54 (m, 1 H), 1.84 (m, 2 H), 2.07 (m, 1 H), 2.18 (m, 2 H), 2.57 (m, 2 H), 2.71 (m, 2 H), 3.11 (m, 1 H), 3.27 (m, 2 H), 7.39 (d, J=9 Hz, 2 H), 7.64 (d, J=9 Hz, 2 H), 7.79 (s, 4 H); (DCl/NH3) m/z 317 (M+H)+.

1. temperatureat reflux for 5 hrs
2. customThe mixture was partitioned between ethyl acetate (25 mL) and H2O (10 mL)
3. washThe organic layer was washed with brine
4. dry with materialdried with magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. customchromatographed on silica gel
8. washeluting with 3% (9:1 MeOH:conc NH4OH) in dichloromethane