反应详情

4 mmol of (R)-4-{5-[1-(2-Phenoxy-acetyl)-piperidin-2-yl]-[1,2,4]oxadiazol-3-yl}-benzoic acid benzyl ester were dissolved in MeOH and treated with Pd/C and flushed with hydrogen (3 bar) and stirred for 30 min. The catalyst was filtered off and the solvent evaporated. After extraction from ethylacetate/water the resulting oil was purified via preperative HPLC. The corresponding alkylesters were treated with aq. 2N NaOH or LiOH in methanol at room temperature. The allylester can be cleaved using Pd(Ph3)4 as catalyst and morpholine as a nucleophile.

1. customflushed with hydrogen (3 bar)
2. filtrationThe catalyst was filtered off
3. customthe solvent evaporated
4. extractionAfter extraction from ethylacetate/water the resulting oil
5. customwas purified via preperative HPLC
6. additionThe corresponding alkylesters were treated with aq. 2N NaOH or LiOH in methanol at room temperature